Figure 10.

Paw withdrawal thresholds on the von Frey mechanical allodynia measure in male (A) and female (B) rats during post-weaning, adolescence, and adulthood in the undisturbed, vehicle, and inflammation groups (all N’s identical to that of Figure 9). Paw withdrawal latencies on the Hargreaves thermal hyperalgesia measure for male (C) and female (D) rats during post-weaning, adolescence, and adulthood in the undisturbed, vehicle, and inflammation groups. These data highlight that rats in each condition, age, and sex have a high withdrawal threshold (mechanical sensitivity) indicating a ceiling effect in these animals. Likewise, a lack of group differences in rats on the thermal hyperalgesia measure may also suggest a ceiling effect.