Table 3.
False-positive report probability values for associations between cancer risk and MnSOD Val16Ala polymorphism.
| Genotype | Crude OR (95% CI) | P valuea | Statistical powerb | Prior probability | ||||
|---|---|---|---|---|---|---|---|---|
| 0.25 | 0.1 | 0.01 | 0.001 | 0.0001 | ||||
| All | ||||||||
| Homozygous | 1.09 (1.00–1.19) | 0.054 | 1.000 | 0.140 | 0.328 | 0.843 | 0.982 | 0.998 |
| Heterozygous | 1.07 (1.02–1.12) | 0.004 | 1.000 | 0.011 | 0.032 | 0.267 | 0.787 | 0.974 |
| Dominant | 1.08 (1.02–1.14) | 0.005 | 1.000 | 0.016 | 0.045 | 0.343 | 0.840 | 0.981 |
| Allele comparison | 1.06 (1.02–1.11) | 0.013 | 1.000 | 0.038 | 0.106 | 0.567 | 0.930 | 0.992 |
| Cancer type—prostate cancer | ||||||||
| Heterozygous | 1.14 (1.05–1.24) | 0.002 | 1.000 | 0.007 | 0.020 | 0.183 | 0.693 | 0.958 |
| Dominant | 1.14 (1.05–1.23) | 0.001 | 1.000 | 0.002 | 0.006 | 0.067 | 0.420 | 0.879 |
| Allele comparison | 1.07 (1.00–1.15) | 0.066 | 1.000 | 0.165 | 0.372 | 0.867 | 0.985 | 0.998 |
| Ethnicity—Asian | ||||||||
| Homozygous | 1.82 (1.15–2.88) | 0.011 | 0.204 | 0.134 | 0.317 | 0.836 | 0.981 | 0.998 |
| Recessive | 1.76 (1.16–2.68) | 0.008 | 0.228 | 0.100 | 0.249 | 0.785 | 0.974 | 0.997 |
| Ethnicity–Caucasian | ||||||||
| Heterozygous | 1.08 (1.03–1.13) | 0.001 | 1.000 | 0.003 | 0.008 | 0.078 | 0.462 | 0.896 |
| Dominant | 1.08 (1.02–1.14) | 0.005 | 1.000 | 0.016 | 0.045 | 0.343 | 0.840 | 0.981 |
| Allele comparison | 1.04 (1.00–1.09) | 0.102 | 1.000 | 0.234 | 0.478 | 0.910 | 0.990 | 0.999 |
| Control source—PB | ||||||||
| Homozygous | 1.10 (1.01–1.19) | 0.018 | 1.000 | 0.050 | 0.136 | 0.634 | 0.946 | 0.994 |
| Heterozygous | 1.07 (1.02–1.12) | 0.004 | 1.000 | 0.011 | 0.032 | 0.267 | 0.787 | 0.974 |
| Dominant | 1.07 (1.02–1.13) | 0.015 | 1.000 | 0.043 | 0.119 | 0.599 | 0.938 | 0.993 |
| Allele comparison | 1.04 (1.00–1.08) | 0.042 | 1.000 | 0.111 | 0.273 | 0.805 | 0.977 | 0.998 |
| Control source—HB | ||||||||
| Recessive | 1.16 (1.01–1.34) | 0.044 | 1.000 | 0.116 | 0.282 | 0.812 | 0.978 | 0.998 |
| Allele comparison | 1.13 (1.03–1.24) | 0.010 | 1.000 | 0.029 | 0.082 | 0.495 | 0.908 | 0.990 |
| Quality score—low | ||||||||
| Allele comparison | 1.12 (1.02–1.23) | 0.018 | 1.000 | 0.051 | 0.138 | 0.637 | 0.947 | 0.994 |
| Quality score—high | ||||||||
| Homozygous | 1.08 (1.00–1.17) | 0.059 | 1.000 | 0.151 | 0.349 | 0.855 | 0.983 | 0.998 |
| Heterozygous | 1.07 (1.02–1.13) | 0.015 | 1.000 | 0.043 | 0.119 | 0.599 | 0.938 | 0.993 |
| Dominant | 1.07 (1.02–1.14) | 0.036 | 1.000 | 0.098 | 0.247 | 0.783 | 0.973 | 0.997 |
| Allele comparison | 1.04 (1.00–1.09) | 0.102 | 1.000 | 0.234 | 0.478 | 0.910 | 0.990 | 0.999 |
aChi-square test was used to calculate the genotype frequency distributions; bstatistical power was calculated using the number of observations in the subgroup and the OR and P values in this table.