(b) 8 downregulated MeDEGs identified in SSc

H U G O a	HUGO gene n a m e a : function b	Function in SSc or related pathology and reference
CXCR6	C-X-C Motif Chemokine Receptor 6, receptor for the C-X-C chemokine CXCL16	Angiogenesis [37, 38]
F2R	Coagulation Factor II Thrombin Receptor	Coagulation/fibrolytic system, fibrosis [39–41]
FYN	Src Family Tyrosine Kinase	Fibrosis [40, 42]
PAG1	Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1	Proliferation of lymphocytes
PRF1	Perforin 1, pore forming protein 1, crucial effector of T and NK cell-mediated cytolysis, highly homologous to complement component C9	cytotoxic activity [43–45] vascular damage [46]
PRKCH	Protein Kinase C Eta, calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine	Associated in stroke, but no report in SSc or related diseases
RASSF5	Ras Association Domain Family Member 5, Potential tumor suppressor.	No report on SSc or related disease
RUNX3	Runt Related Transcription Factor 3	Transcription factor, induction and suppressive function of Foxp3+ inducible T reg [47]

http://www.genecards.org.

^aHuman Genome Organization nomenclature.

^bGene function from GeneCards website.