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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Exp Neurol. 2018 Jul 25;309:32–43. doi: 10.1016/j.expneurol.2018.07.013

Figure 1. Compensatory axon sprouting is a CNS repair mechanism distinct from axon regeneration.

Figure 1.

There are two forms of injury-induced axonal growth: regeneration, axonal growth from injured neurons; and sprouting, compensatory axonal growth from uninjured neurons. After a partial CNS injury that severs axons from a subset of neurons (as exemplified by the neuron in dark red), uninjured neurons (black) may exhibit spontaneous compensatory axon sprouting into denervated regions (green), a process distinct from axon regeneration from injured neurons (purple).