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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Exp Neurol. 2018 Jul 25;309:32–43. doi: 10.1016/j.expneurol.2018.07.013

Figure 3. Inducible deletion of Nogo from oligodendrocytes promotes compensatory sprouting of corticospinal tract axons.

Figure 3

(A) Drawing of the unilateral pyramidotomy model with a dorsal view of the brain. Note that, at the level of the pyramid, unilateral pyramidotomy is performed at the most ventral part of the brain. (B) BDA-labeled CST axons in cervical sections from Nogof/f;no Cre and Nogof/f;PLPCreERT mice after unilateral pyramidotomy. White box depicts enlarged region shown in right panels. Scale bars = 500 μm (low mag, left), 100 μm (high mag, right). (C) Quantification of the number of BDA-labeled axons at specific distances from the midline in the denervated side of the spinal cord normalized to the total labeled CST axon count at the medulla in Nogof/f;no Cre (n=8) and Nogof/f;PLPCreERT (n=12) mice. *p <05, two-way RM ANOVA followed by Fisher’s least significant difference test. Error bar, SEM.