Table 6.
Selected outcomes at 12 months.
| Overall, n = 34 median [IQR]/mean (sd) | rhGH n = 16 median [IQR]/mean (sd) | Placebo n = 18 median [IQR]/mean (sd) | p-value | |
|---|---|---|---|---|
| Disability Rating Scale (DRS) | 0.0 [0.0, 4.0] | 0.5 [0.0, 3.0] | 0.0 [0.0, 4.0] | 0.73 |
| Galveston Orientation Assessment Test (GOAT) | 100 [87.0, 100] | 99.5 [91.0, 100] | 100 [87.0, 100] | 0.93 |
| Digit span age standardized score | 11.0 [8.0, 13.0] | 10.5 [8.0, 14.5] | 11.0 [9.0, 13] | 0.93 |
| Processing speed index age standardized score | 88.0 [79.0, 99.0] | 86.0 [76.0, 111] | 89.5 [81.0, 99.0] | 0.90 |
| Digit symbol age standardized score | 8.0 [6.0, 9.0] | 8.0 [6.0, 12.0] | 8.0 [6.0, 9.0] | 0.68 |
| Symbol search age standardized score | 9.0 [6.0, 11.0] | 9.0 [6.0, 12.0] | 9.0 [7.0, 11.0] | 0.97 |
| California Verbal Learning Test (CVLT) T score | 43.5 [32.0, 59.0] | 41.0 [28.5, 62.0] | 47.0 [41.0, 59.0] | 0.37 |
| Trails A T score | 49.0 [44.0, 55.0] | 47.0 [26.0, 56.0] | 51.0 [44.0, 55.0] | 0.56 |
| Trails B T score | 52.0 [46.0, 62.0] | 50.0 [35.0, 62.0] | 54.0 [48.0, 62.0] | 0.38 |
| Controlled Oral Word Association Test (COWA) T score | 38.0 [30.0, 47.0] | 33.0 [22.0, 47.0] | 38.0 [34.0. 49.0] | 0.30 |
| Brief Symptom Inventory (BSI)—Average T score | 50.3 [45.5, 60.9] | 56.6 [44.8, 63.0] | 49.6 [47.9, 56.6] | 0.82 |
| Functional Independence Measure (FIM) Motor | 113.5 (14.9) | 115.9 (8.0) | 111.4 (19.1) | 0.56 |
| FIM cognitive | 31.7 (4.3) | 32.2 (3.3) | 31.3 (5.2) | 0.87 |
| FIM total | 142.5 (17.5) | 148.1 (9.5) | 142.7 (22.4) | 0.85 |
| FIM motor change from baseline admit | 74.8 (21.5) | 83.7 (18.6) | 66.8 (21.2) | 0.02 |
| FIM cognitive change from baseline admit | 22.7 (6.1) | 24.9 (5.6) | 20.8 (6.0) | 0.05 |
| FIM total change from baseline admit | 97.5 (25.1) | 108.6 (20.9) | 87.6 (24.9) | 0.01 |
| Patient Health Questionnaire (PHQ-9) | 4.7 (6.0) | 6.2 (7.4) | 3.4 (4.2) | 0.54 |
| Fatigue severity scale | 25.4 (14.0) | 24.3 (13.8) | 26.5 (14.6) | 0.54 |
| Rivermead post-concussion symptoms questionnaire | 11.1 (10.6) | 11.1 (9.9) | 11.1 (11.5) | 0.86 |
| Satisfaction with life scale | 22.7 (8.1) | 23.4 (8.5) | 22.1 (8.0) | 0.58 |
| Short Form health survey (SF 36)—Physical health | 277.7 (31.9) | 287.8 (33.8) | 268.1 (27.6) | 0.08 |
| Short Form health survey (SF 36)—Mental health | 245.7 (48.0) | 244.9 (59.2) | 246.4 (36.3) | 0.54 |
| 12 month Glascow Outcome Score-Extended (GOSE) score | 0.59 | |||
| 3—Severe disability | 4 | 1 | 3 | |
| 4 | 4 | 3 | 1 | |
| 5—Moderate disability | 1 | 0 | 1 | |
| 6 | 8 | 4 | 4 | |
| 7—Good recovery | 5 | 1 | 4 | |
| 8 | 12 | 7 | 5 |
2-sided p-value (α = 0.05) from PROC NPAR1WAY Wilcoxon Rank sum test. Bold values highlight those that meet the pre-specified nominal threshold for statistical significance (p < 0.05).