Table 3.

Wilcoxon signed‐rank test comparison of Pmax and area under the curve (AUC) of boiled soybean (BS) and Cheonggukjang (CGJ) treatment in sham and ovariectomized (OVX) mice.

No.	Group of metabolites	Metabolite	P max (PA mL–1)		AUC (0–24 h, PA mL–1)
			Sham	OVX	Sham	OVX
			BS‐CGJ	BS‐CGJ	BS‐CGJ	BS‐CGJ
1	Isoflavone	Genistein	–	–	<0.05	<0.01
2		Daidzein	–	–	<0.001	–
3		Glycitein	–	–	–	–
4	Phase I (Liver)	3‐Hydroxygenistein	–	–	–	<0.05
5		6‐Hydroxydaidzein	–	–	–	<0.05
6	Phase II (Liver)	Genistein 4′‐glucuronide	–	<0.001	–	–
7		Genistein 7‐glucuronide	–	–	–	–
8		Genistein 4′‐sulfate	<0.05a)	–	<0.05a)	<0.05
9		Genistein 7‐sulfate	–	–	–	–
10		Daidzein 7‐glucuronide	–	–	<0.01a)	–
11		Daidzein 4′‐sulfate	<0.001a)	–	<0.01a)	–
12		Methylgenistein	–	<0.001a)	–	–
13		Formononetin	–	–	<0.01a)	<0.001a)
14	Gut‐mediated metabolites	Dihydrogenistein	–	–	–	<0.05
15		Dihydrogenistein sulfate	–	–	–	<0.05
16		Dihydrodaidzein	–	–	–	<0.05
17		Dihydrodaidzein sulfate	–	–	–	<0.05
18		Equol 7‐glucuronide	–	–	<0.01a)	<0.05
19		Equol 4′‐sulfate	<0.01a)	<0.001a)	<0.05a)	–
20		5‐hydroxy equol	–	–	–	<0.05
21		Hippuric acid	–	–	–	–
22		4‐hydroxybenzoic acid	–	–	<0.01a)	<0.05a)
23		2,6‐Dimethoxy benzoic acid	–	–	–	–
24		Caffeic acid	–	–	–	<0.05a)
25		Methyl caffeic acid	–	–	–	<0.05a)
26		Fumaric acid	–	–	–	–
27		4‐Ethylphenol	–	–	–	–
28		Glutaric acid	–	–	–	<0.05
29		2‐Phenylpropanoic acid	–	–	–	–
30		p‐Coumaric acid	–	–	<0.01a)	<0.05
31		Gallic aicd	–	–	–	<0.05
32		Ferulic acid	–	–	–	–
33		Resorcinol	–	–	–	–
34		Resorcinol sulfate	–	–	–	–

a)Metabolites that were significantly increased in the BS‐treated group compared with the CGJ‐treated group.