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. 2018 Sep 10;9:1023. doi: 10.3389/fphar.2018.01023

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Copyright © 2018 Ahmad-Molaei, Hassanian-Moghaddam, Farnaghi, Tomaz and Haghparast.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Locomotor activity was recorded by using photobeam activity system during a 5-min session in different groups, including; M/N-treated groups (a single dose of naloxone was administered after methadone overdose in apnea stage, in animals which experienced apnea and locomotor activity was evaluated either on day 1, 5, or 10 day post-resuscitation; M/N-Day 1 (n = 10), M/N-Day 5 (n = 6) and M/N-Day 10 (n = 6) groups and their respective Saline control groups; n = 6; right panel), M/N-Sedate (n = 11; a single dose of naloxone was administered after methadone overdose immediately in the initial stage of sedation state, so behavioral evaluation was carried out only 1 day after drug administration), Saline; n = 14, methadone; n = 12 and naloxone; n = 8 (saline, methadone or naloxone was administered alone in separated groups in which locomotor activity was evaluated 1 day after drug administration) groups. Animals received methadone (15 mg/kg; i.p.) or naloxone (2 mg/kg; i.p.) alone or both in a single dose. Administration of toxic dose of methadone did not change locomotor activity in all groups. Each bar shows the mean ± SEM for 6–14.