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. 2018 Apr 25;120(2):662–680. doi: 10.1152/jn.00862.2017

Fig. 7.

Fig. 7.

Comparison of subthalamic nucleus (STN) deep brain stimulation (DBS)-induced cortical evoked potential (cEP) response between species: rat (A) and human (B). A: cEP response to 4.5-Hz STN DBS in healthy, awake rats. B: cEP response over the sensory-motor region of the cortex (C4) during 20-Hz STN DBS in a patient with Parkinson’s disease (recordings are from a study by Walker et al. 2012). Note the cEP response from both rats and human comprised R1, R2, and R3 components, although the R2 and R3 responses occurred at somewhat shorter latencies in human (R2: 5.7 ± 1.1 ms; R3: 22.2 ± 1.8 ms) than in rats (R2: 8.33 ± 0.73 ms; R3: 27.77 ± 2.42 ms). Furthermore, the cEP in rats was averaged across 6 rats, whereas the human cEP is from a single patient. cEP responses from each of these 6 rats are shown in Fig. 5.