Table 4.
Top 30 genes significantly regulated by binge drinking in male nucleus accumbens.
| Gene symbol | Gene name | Male | ||
|---|---|---|---|---|
| Fold change | p-value | q-value | ||
| Fasl | Fas ligand (TNF superfamily, member 6) | 20.15 | 0.016 | 0.064 |
| Chrna1 | Cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) | 15.31 | 0.019 | 0.064 |
| Slc6a2 | Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 | 10.49 | 0.000 | 0.016 |
| Crh | Corticotropin releasing hormone | 5.32 | 0.041 | 0.066 |
| Ptgs2 | Prostaglandin-endoperoxide synthase 2 | 4.66 | 0.009 | 0.064 |
| Bdnf | Brain derived neurotrophic factor | 4.26 | 0.008 | 0.064 |
| Crhr2 | Corticotropin releasing hormone receptor 2 | 2.07 | 0.022 | 0.064 |
| Tuba8 | Tubulin, alpha 8 | 1.96 | 0.016 | 0.064 |
| Mc5r | Melanocortin 5 receptor | 1.93 | 0.024 | 0.064 |
| Cpt2 | Carnitine palmitoyltransferase 2 | 1.91 | 0.025 | 0.064 |
| Lta | Lymphotoxin A | 1.88 | 0.027 | 0.064 |
| Dusp6 | Dual specificity phosphatase 6 | 1.86 | 0.023 | 0.064 |
| Homer2 | Homer homolog 2 (Drosophila) | 1.83 | 0.027 | 0.064 |
| Slc6a3 | Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 1.80 | 0.028 | 0.064 |
| Gabra1 | Gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 | 1.67 | 0.045 | 0.066 |
| Grm4 | Glutamate receptor, metabotropic 4 | -2.19 | 0.019 | 0.064 |
| Npas2 | Neuronal PAS domain protein 2 | -2.20 | 0.011 | 0.064 |
| Drd5 | Dopamine receptor D5 | -2.30 | 0.021 | 0.064 |
| Rap1gap | Rap1 GTPase-activating protein | -2.37 | 0.033 | 0.065 |
| Ccl3 | Chemokine (C-C motif) ligand 3 | -2.40 | 0.049 | 0.066 |
| Smc4 | Structural maintenance of chromosomes 4 | -2.48 | 0.017 | 0.064 |
| Bcr | Breakpoint cluster region | -2.52 | 0.030 | 0.065 |
| Htr1b | 5-hydroxytryptamine (serotonin) receptor 1B | -2.80 | 0.022 | 0.064 |
| Isyna1 | Myo-inositol 1-phosphate synthase A1 | -2.88 | 0.015 | 0.064 |
| Ace | Angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | -3.19 | 0.023 | 0.064 |
| Bax | BCL2-associated X protein | -3.47 | 0.032 | 0.065 |
| Drd1 | Dopamine receptor D1 | -3.51 | 0.011 | 0.064 |
| Cit | Citron | -3.96 | 0.010 | 0.064 |
| Tfap2b | Transcription factor AP-2 beta | -15.01 | 0.000 | 0.013 |
| S100a9 | S100 calcium binding protein A9 (calgranulin B) | -24.14 | 0.026 | 0.064 |
The 15 most highly up- or down-regulated transcripts by binge drinking in males are shown. Significance is based on p-values, but q-values also are shown. Transcripts are listed in ascending order. Fold change of binge vs. control is shown, with positive values indicating up-regulation and negative values indicating down-regulation by ethanol. Some of the genes with high fold changes (Fasl, Chrna1, Slc6a2, and S100a9) had 2 or more samples with undetected expression, indicating qualitative regulation (i.e., present in binge, absent in control).