Fig. 2.
Diurnal cortisol index as measured by salivary cortisol before and after 20 wk of gonadotropin-releasing hormone agonist (GnRHAG) + PL (A) or GnRHAG + E2 (B) add-back therapy in premenopausal women. Saliva samples were collected at three time points in the evening before bed (2130, 2200, and 2230) and at three time points upon awakening in the morning [immediately after awakening (wake), 30 min after awakening (wake + 0.5), and 1 h after awakening (wake + 1)]. n = 15 participants per group. Data presented as means ± standard error (SE). E2, estradiol; PL, placebo.