Table 3.
Body composition before and after 20 wk of gonadotropin-releasing hormone agonist plus add-back of PL or E2
| GnRHAG + PL, n = 15 |
GnRHAG + E2, n = 15 |
|||||||
|---|---|---|---|---|---|---|---|---|
| Variable | Before intervention | After intervention | Within-group change (95% CI) | Before intervention | After intervention | Within-group change (95% CI) | Between-group difference in change* (95% CI) | P value |
| BMI, kg/m2 | 27 ± 1.6 | 26 ± 1.6 | −0.2 (−0.7, 0.2) | 27 ± 1.6 | 27 ± 1.6 | −0.1 (−0.9, 0.7) | −0.1 (−1.0, 0.8) | 0.81 |
| Total mass, kg | 74.7 ± 4.8 | 74.0 ± 4.9 | −0.7 (−1.9, 0.5) | 75.3 ± 5.3 | 74.7 ± 5.1 | −0.5 (−2.9, 1.8) | −0.2 (−2.7, 2.4) | 0.88 |
| Fat-free mass, kg | 47.4 ± 1.8 | 47.1 ± 1.7 | −0.3 (−0.9, 0.3) | 48.6 ± 2.0 | 48.8 ± 1.8 | 0.1 (−0.7, 1.0) | −0.5 (−1.4, 0.3) | 0.20 |
| Fat mass, kg | 27.2 ± 3.3 | 26.8 ± 3.4 | −0.4 (−1.6, 0.8) | 26.6 ± 3.6 | 26.0 ± 3.7 | −0.7 (−2.6, 1.3) | 0.3 (−2.0, 2.5) | 0.80 |
| Abdominal fat area, cm2 | 358 ± 52.1 | 368 ± 55.0 | 10.1 (−8.5, 28.7) | 341 ± 51.4 | 338 ± 55.2 | −3.4 (−29.0, 22.3) | 12.7 (−17.4, 42.8) | 0.39 |
| Abdominal SAT area, cm2 | 285 ± 37.3 | 293 ± 39.9 | 8.0 (−7.5, 23.6) | 280 ± 44.4 | 278 ± 47.9 | −2.1 (−23.6, 19.4) | 9.9 (−15.1, 34.8) | 0.43 |
| Abdominal VAT area, cm2 | 72.4 ± 16.8 | 74.4 ± 17.3 | 2.1 (−3.3, 7.5) | 61.0 ± 9.3 | 59.8 ± 9.6 | −1.2 (−6.6, 4.1) | 3.2 (−4.3, 10.6) | 0.39 |
Values are means ± SE or mean (95% CI). n = no. of participants. BMI, body mass index; CI, confidence interval; E2, estradiol; GnRHAG, gonadotropin-releasing hormone agonist; PL, placebo; SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue.
*
Difference in change is group difference in change controlling for before intervention value.