Fig. 1.

Pioglitazone restores adipose tissue gene expression in mice with nonalcoholic steatohepatitis (NASH). Changes in adipose tissue genes involved in fatty acid metabolism and inflammation: (A) Ppara, (B) Pparg, (C) Il6, (D) Tnfa, and (E) Ucp2, with pioglitazone treatment points to its beneficial effects on adipose tissue insulin sensitivity and function. Data are represented as means ± SE (n = 4–5). *P ≤ 0.05 between control (C) and high-transfat/high-fructose fed (TFD); #P ≤ 0.05 between TFD and TFD + pioglitazone (PIO); $P ≤ 0.05 between C and PIO. mice; PIO, mice fed TFD diet supplemented with pioglitazone.