Fig. 8.
Schematic summary of the main phenotypic changes of nuclear factor erythroid 2-related factor 2 knockout (Nrf2−/−) mice compared with wild-type mice (based on references) and of Nrf2flox/flox::Albumin-Cre (HeNKO) and Nrf2flox/flox::Adipoq-Cre (ANKO) mice versus Control after long-term exposure to high-fat diet. Arrows pointing upward indicate increase, arrows pointing downward indicate decrease, horizontal left-right arrows mean no change, and arrows with two intersecting lines indicate trend. BW/F, body weight and body fat; chol, serum cholesterol; EE, energy expenditure; IR, insulin resistance; GT, glucose tolerance; NEFA, serum nonesterified fatty acids; TG, serum triglycerides.