Fig. 6.

Protein and DNA breakdown in cultured myoblasts during an H₂O₂ challenge. A: Compared with CON + H₂O₂, H₂O₂+ Protandim (Pro) lowered the DNA fractional breakdown rate (FBR, A), B) mitochondrial (Mito) FBR (B), and Cyto FBR (D). C: compared with CON + H₂O₂, H₂O₂ + VitC lowered the ratio of Mito protein to DNA breakdown, as did H₂O₂ + EtOH, indicating reduced proteostatic maintenance. E: compared with CON + H₂O₂, H₂O₂ + Pro increased the ratio of cytosolic (Cyto) protein to DNA FBR. Data were assessed by 1-way ANOVA with planned contrasts and presented as means ± SE. *P < 0.05; n = 3/condition.