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. 2018 Apr 18;315(2):F223–F230. doi: 10.1152/ajprenal.00050.2018

Fig. 6.

Fig. 6.

Renal K+ excretion is normal in kidney-specific-with-no-lysine kinase-null (KS-WNK1−/−) mice. A: bar graph shows the results of experiments in which the effect of a single dose hydrochlorothiazide (HCTZ) on urinary K+ excretion (EK) within 120 min was measured with renal clearance method in wild-type (WT) or KS-WNK1−/− mice on normal potassium (NK) (1% K+) and high potassium (HK) (5% K+) diets, respectively. B: bar graph shows the results (n = 6 mice for each group) of experiments in which the effect of single dose HCTZ on urinary Na+ excretion (ENa) within 120 min was measured with renal clearance method in WT or KS-WNK1−/− mice on 1% and 5% K+ diets, respectively. *Significant difference as determined by Studentʼs t test (P < 0.05). #Significant difference as determined by Studentʼs t test and two-way ANOVA (P < 0.05).