Table 1.

Urine and serum ion concentrations

	Sodium		Chloride		Potassium
Length of Lithium Treatment	Urine, meq/mg	Serum, meq/l	Urine, meq/mg	Serum, meq/l	Urine, meq/mg	Serum, meq/l
Control	1.807 ± 1.178	139.5 ± 0.481	2.780 ± 0.269	102.7 ± 1.858	3.855 ± 0.331	5.493 ± 0.961
1 Week	1.681 ± 0.224	139.4 ± 0.971	2.502 ± 0.521	107.8 ± 0.752	2.493 ± 0.273	5.938 ± 0.582
2 Weeks	2.659 ± 0.696	132.2 ± 8.582	6.763 ± 1.905	105.7 ± 6.756	5.206 ± 1.447	6.097 ± 0.707
3 Weeks	3.277 ± 0.650	137.5 ± 1.391	3.448 ± 0.616	107.0 ± 0.338	4.004 ± 1.113	8.077 ± 1.172
6 Weeks	4.836 ± 0.953*	149.1 ± 4.661	5.138 ± 1.351	113.8 ± 5.607	6.420 ± 1.606	4.857 ± 0.049
9 Weeks	6.386 ± 1.269*	139.0 ± 1.822	3.401 ± 1.268	110.1 ± 1.457	6.390 ± 2.316	9.180 ± 0.042
12 Weeks	3.354 ± 0.249	148.3 ± 3.300	2.401 ± 0.076	114.7 ± 3.300	5.112 ± 1.682	7.680 ± 0.176

Data are expressed as means ± SE and subjected to a Kruskal-Wallis one-way ANOVA and Tukey’s post hoc test. Serum sodium, chloride, and potassium were measured by EasyLyte. Urinary sodium, chloride, and potassium levels were also measured by EasyLyte and normalized to urinary creatinine to compensate for varying urine volume. Concentrations are presented as normalized to urinary creatinine. Control, n = 11; 1 wk, n = 7; 2 wk, n = 6; 3 wk, n = 8; 6 wk, n = 10; 9 wk, n = 3; 12 wk, n = 3.

^*P < 0.05 vs. control.