Table 1.
Body weight and food and water intake under basal conditions and in response to empagliflozin
| Oat1 |
Oat3 |
|||
|---|---|---|---|---|
| WT | −/− | WT | −/− | |
| Body weight, g | ||||
| Basal | 31.8 ± 1.0 | 32.9 ± 1.5 | 28.5 ± 0.9 | 30.7 ± 0.7 |
| Rmpagliflozin | 30.3 ± 0.8* | 31.2 ± 1.1* | 27.5 ± 0.8* | 29.6 ± 0.6* |
| Food intake, g | ||||
| Basal | 5.90 ± 0.66 | 4.97 ± 0.33 | 4.53 ± 0.32 | 4.78 ± 0.17 |
| Empagliflozin | 9.87 ± 3.15 | 7.23 ± 1.13 | 4.49 ± 0.15 | 5.16 ± 0.68 |
| Water intake, g | ||||
| Basal | 3.77 ± 0.08 | 3.84 ± 0.29 | 3.63 ± 0.25 | 3.57 ± 0.16 |
| Empagliflozin | 6.51 ± 0.32* | 6.47 ± 0.45* | 5.98 ± 0.17* | 6.77 ± 0.52* |
Values are means ± SE. Mean data per mouse were calculated. Body weight, n = 8–11 in each group; and food intake and water intake, n = 4 cages in each group with 2–3 mice/cage.
P < 0.05 vs basal.