Table 1.

Parameters of I-V relationships

Values for V½ and k were obtained from Boltzmann fits of data in Fig. 2A. Results were obtained from six independent experiments, and p values were determined by t test. pA/pF, picoamperes/picofarads.

Channel	WT	n	Mutant	n	p value
CaV1.3
V½ (mV)	−9.9 ± 1.4	10	−6.8 ± 1.2	11	0.12
k	7.1 ± 0.5		10.2 ± 1.2		0.03
ICa density (pA/pF)	−25.6 ± 3.3		−14.5 ± 2.8		0.02
CaV2.1
V½ (mV)	−2.4 ± 1.1	8	0.7 ± 1.4	9	0.11
k	3.1 ± 0.5		3.6 ± 0.5		0.51
ICa density (pA/pF)	−72.8 ± 12		−30.1 ± 7.8		0.03
CaV3.1
V½ (mV)	−41.8 ± 1.2	11	−40.7 ± 0.8	14	0.43
k	3.3 ± 0.4		3.4 ± 0.4		0.83
ICa density (pA/pF)	−165.5 ± 14		−67.9 ± 13		<0.01