Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Parameters for voltage-dependent inactivation
Values for V½ and k were obtained from Boltzmann fits of data in Fig. 5A. Results were obtained from nine independent experiments, and p values were determined by t test.
| Channel | WT | n | Mutant | n | p value |
|---|---|---|---|---|---|
| CaV1.3 | |||||
| V½ (mV) | −24.6 ± 2.1 | 7 | −21.5 ± 1.9 | 7 | 0.31 |
| k | −4.9 ± 0.5 | −9.5 ± 0.8 | <0.01 | ||
| CaV2.1 | |||||
| V½ (mV) | −18 ± 0.8 | 8 | −6.1 ± 2.5 | 8 | <0.01 |
| k | −3.0 ± 0.4 | −4.3 ± 0.9 | 0.27 | ||
| CaV3.1 | |||||
| V½ (mV) | −62.5 ± 0.8 | 7 | −60.5 ± 1 | 7 | 0.24 |
| k | −3.9 ± 0.1 | −3.4 ± 0.1 | 0.04 | ||
