Table 3.
Parameters for voltage-dependent activation
Values for V½ and k were obtained from Boltzmann fits of data in Fig. 5B; n represents number of cells. Results were obtained from nine independent experiments and p values were determined by t test.
| Channel | WT | n | Mutant | n | p value |
|---|---|---|---|---|---|
| CaV1.3 | |||||
| V½ (mV) | −7.8 ± 1.6 | 9 | −5.6 ± 1.5 | 10 | 0.36 |
| k | 8 ± 0.9 | 10.3 ± 0.8 | 0.10 | ||
| CaV2.1 | |||||
| V½ (mV) | 8.6 ± 1.6 | 7 | 11.8 ± 1.4 | 8 | 0.21 |
| k | 7.5 ± 0.5 | 5.7 ± 1 | 0.24 | ||
| CaV3.1 | |||||
| V½ (mV) | −37.1 ± 0.9 | 7 | −32.4 ± 0.9 | 8 | <0.01 |
| k | 3.3 ± 0.3 | 4.7 ± 0.4 | 0.03 | ||