Figure 4.

Light-induced degradation of an activator accurately simulates Neurospora’s PRC. (A) In both the simple model and Dovzhenok model, a 5-min light pulse increasing the degradation rate of an activator induces PRCs that match well with experimental data (Fig. 2A). Here, the 5-min pulse increases β_w (degradation rate of WCC) from 0.012 to 0.812 h⁻¹ in the simple model and k₁₂ (degradation rate of nuclear WCC) from 0.02 to 3.52 h⁻¹ in the Dovzhenok model. (B and C) WCC protein (B) and frq mRNA (C) profiles of the Dovzhenok model after pulses are applied in the advance region (pink circle), the dead zone (green triangle), or the delay region (purple star) are shown. Black dashed lines represent the time courses of WCC protein (B) and frq mRNA (C) in the absence of a pulse. To see this figure in color, go online.