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. 2018 May 18;315(2):H348–H356. doi: 10.1152/ajpheart.00693.2017

Fig. 1.

Fig. 1.

Tissue-specific elimination of APJ. A: floxed APJ construct for APJ elimination. B: RNA expression in whole heart (APJendo+/+: 1 ± 0.6 vs. APJendo−/−: 0.003 ± 0.007, n = 8 and 6, P = 0.002) and in situ hybridization to APJ transcripts depicting expression of APJ in cardiomyocytes of APJendo−/− and APJendo+/+ hearts. Red stain indicated by black arrows indicates RNA expression; hematoxylin stained cardiomyocyte nuclei blue. C: RNA expression in whole heart (APJmyo+/+: 1.0 ± 0.3 vs. APJmyo−/−: 0.66 ± 0.2, n = 7 and 4, P = 0.05) and in situ hybridization to APJ transcripts depicting expression of APJ in cardiomyocytes of APJmyo−/− and APJmyo+/+ hearts. Red stain indicated by black arrows indicates RNA expression; hematoxylin stained nuclei blue.