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p.503L Ca2+-activated K+ channel subfamily N member 2 (KCNN2) channels that have already bound ondansetron only poorly respond to apamin. Top: representative ramp currents recorded in p. KCNN2-transfected human embryonic kidney (HEK)-293 cells in control (black), in ondansetron alone (red), and in apamin + ondansetron (green). Concentrations of apamin and ondansetron are as shown. Bottom: plots of currents at 0 mV as a function of time for the same cells shown in the top.
