Table 1.
RGS B/R4 family members
| Member | Interactions | Vascular | Receptor Association | Refs. |
|---|---|---|---|---|
| RGS1 | Gαi/Gαq | no | ANG, sphingosine-1 | (13, 89, 122) |
| RGS2 | Gαi/Gαq (and AC) | yes | ANG, ET-1, AVP, α1/β2AR, muscarinic, CCK2 | (15, 23, 64, 89, 107, 122, 128, 151, 152, 188, 191, 193, 198, 199) |
| RGS3 | Gαi/Gαq/Gαz/Gαo | yes | ET-1, sphingosine-1, GnRH, M1/M3 muscarinic, βAR | (21, 89, 90, 120, 121, 139, 164) |
| RGS4 | Gαi/Gαq/Gαz | yes | Kir3, ANG, ET-1, muscarinic | (81, 133, 151, 153, 185, 192, 209) |
| RGS5 | Gαi/Gαq/Gαo | yes | ANG, ET-1, muscarinic | (10, 26, 54, 68, 141, 215) |
| RGS8 | Gαi/Gαq/Gαo | yes | ANG, GIRK, M1 muscarinic | (79, 154, 179, 187) |
| RGS13 | Gαi/Gαq/Gαo | yes | sphingosine-1, muscarinic, CXCR | (12, 85, 170) |
| RGS16 | Gαi/Gαq/Gαo | yes | PAF, rhodopsin, GIRK | (14, 22, 86, 213) |
| RGS18 | Gαi/Gαq | no | ANG, M1 muscarinic, OGR1, CCR2 | (80, 119, 134, 207) |
| RGS21 | Gαi/Gαq/Gαo | no | T2R | (20, 31, 194) |
ANG, angiotensin II; AC, adenylyl cyclase; ET-1, endothelin-1; AVP, arginine vasopressin; AR, adrenergic receptor; CCK, cholecystokinin; GnRH, gonadotropin-releasing hormone; Kir, potassium inwardly-rectifying channel; GIRK, G protein-coupled inwardly-rectifying potassium channel; CXCR, C-X-C motif chemokine receptor; PAF, platelet-activating factor receptor; OGR1, Ovarian cancer G-protein coupled receptor 1; CCR2, C-C chemokine receptor type 2; T2R, (TAS2R) taste receptor type 2.