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Signature 3 identifies agents useful for treating airway hyperreactivity. Heatmap illustrating the log2 fold changes of transcripts comprising signature 3 and associated compounds inducing the same (left-most 25 compounds) or opposite (right-most 25 compounds) gene signatures. Compounds were obtained through query of the connectivity map (CMAP). Genes (19/28 and 12/18) had Affymetrix identifiers that could be used in CMAP. Original scale is in log2 fold change.
