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. 2018 Apr 5;315(2):L133–L148. doi: 10.1152/ajplung.00557.2017

Fig. 5.

Fig. 5.

Alverine citrate decreases airway resistance. A: airway resistance in wild-type (WT) mice sensitized to ovalbumin (OVA) and treated intraperitoneally with either 15 mg/kg alverine citrate (ALV) or vehicle control (Veh) during the sensitization protocol and then 30 min before the methacholine (MCh) challenge. Resistance (R) was measured after increasing doses of methacholine. Data are means ± SE. For both conditions, n = 7 mice. *P < 0.05 by 2-way ANOVA. B: baseline airway resistance measured before administration of methacholine. Bronchoalveolar lavage fluid was assayed for total number of cells (C) and percentage of granulocyte cells (D). E: representative hematoxylin and eosin stain of bronchoalveolar lavage fluid from OVA-sensitized WT mice treated with alverine citrate or vehicle control. Arrows indicate examples of granulocytes. Bronchoalveolar lavage concentrations of IL-4 (F), IL-5 (G), and IL-13 (H). I: quantitative RT-PCR of mucin 5AC (muc5AC) mRNA in airways. Individual data points represent data collected from an individual mouse. Bars and whiskers indicate means ± SE.