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. 2018 Apr 5;315(2):L133–L148. doi: 10.1152/ajplung.00557.2017

Table 2.

CMAP compounds that mimicked signature 2

Rank Drug Condition (Reference) Classification/Use
1 Arotinoid acid Arotinoid
2 Folic acid Asthma* (7) Vitamin
3 Levodopa Dopamine agonist
4 Acebutolol Beta adrenergic receptor blocker
5 Alvespimycin HSP90 inhibitor
6 Isoxsuprine Asthma (mixed) (11, 93) Beta adrenergic receptor agonist
7 PHA-00851261E Unknown
8 Sulfabenzamide Antibiotic
9 Cefaclor Antibiotic
10 Iproniazid Bronchoconstriction (5) Antidepressant
11 Amitriptyline Bronchoconstriction (2) Antidepressant
12 Pioglitazone Asthma (55) PPAR agonist
13 Fluorocurarine Sympathetic ganglion blocker
14 Piperacillin Bronchoconstriction* (52) Antibiotic
15 Tanespimycin HSP90 inhibitor
16 Dyclonine Local anesthetic
17 Naftifine Antifungal
18 Alpha ergocryptine Alkaloid
19 Paroxetine Antidepressant
20 Josamycin Antibiotic
21 Mecamylamine Bronchoconstriction (28) Cholinergic antagonist
22 Etanidazole Decreases glutathione
23 Digoxigenin Steroid
24 Medrysone Corticosteroid
25 PF-00539745-00 Unknown

Rank is order of correlation. CMAP, connectivity map; HSP, heat shock protein; PPAR, peroxisome proliferator-activated receptor.

*

Adverse effect.