Table 2.
CMAP compounds that mimicked signature 2
| Rank | Drug | Condition (Reference) | Classification/Use |
|---|---|---|---|
| 1 | Arotinoid acid | Arotinoid | |
| 2 | Folic acid | Asthma* (7) | Vitamin |
| 3 | Levodopa | Dopamine agonist | |
| 4 | Acebutolol | Beta adrenergic receptor blocker | |
| 5 | Alvespimycin | HSP90 inhibitor | |
| 6 | Isoxsuprine | Asthma (mixed) (11, 93) | Beta adrenergic receptor agonist |
| 7 | PHA-00851261E | Unknown | |
| 8 | Sulfabenzamide | Antibiotic | |
| 9 | Cefaclor | Antibiotic | |
| 10 | Iproniazid | Bronchoconstriction (5) | Antidepressant |
| 11 | Amitriptyline | Bronchoconstriction (2) | Antidepressant |
| 12 | Pioglitazone | Asthma (55) | PPAR agonist |
| 13 | Fluorocurarine | Sympathetic ganglion blocker | |
| 14 | Piperacillin | Bronchoconstriction* (52) | Antibiotic |
| 15 | Tanespimycin | HSP90 inhibitor | |
| 16 | Dyclonine | Local anesthetic | |
| 17 | Naftifine | Antifungal | |
| 18 | Alpha ergocryptine | Alkaloid | |
| 19 | Paroxetine | Antidepressant | |
| 20 | Josamycin | Antibiotic | |
| 21 | Mecamylamine | Bronchoconstriction (28) | Cholinergic antagonist |
| 22 | Etanidazole | Decreases glutathione | |
| 23 | Digoxigenin | Steroid | |
| 24 | Medrysone | Corticosteroid | |
| 25 | PF-00539745-00 | Unknown |
Rank is order of correlation. CMAP, connectivity map; HSP, heat shock protein; PPAR, peroxisome proliferator-activated receptor.
*
Adverse effect.