Table 3.
CMAP compounds that mimicked signature 3
| Rank | Drug | Condition (Reference) | Classification/Use |
|---|---|---|---|
| 1 | Imipramine | Antidepressant | |
| 2 | Cinchonine | Alkaloid | |
| 3 | Sulmazole | Bronchoconstriction (60) | Adenosine receptor antagonist |
| 4 | Amrinone | Bronchoconstriction (44) | Phosphodiesterase inhibitor |
| 5 | Droperidol | Bronchoconstriction (73) | Dopamine antagonist |
| 6 | Canadine | Alkaloid | |
| 7 | Domperidone | Asthma (37) | Dopamine antagonist |
| 8 | Naringenin | Asthma (76) | Flavinoid |
| 9 | Amitriptyline | Bronchoconstriction (2) | Antidepressant |
| 10 | Tanespimycin | HSP90 inhibitor | |
| 11 | Diethylstilbestrol | Asthma* (97) | Nonsteroidal estrogen |
| 12 | 2-Aminobenzenesulfonamide | Carbonic anhydrase inhibitor | |
| 13 | Harmaline | Alkaloid | |
| 14 | Furosemide | Asthma (48) | Diuretic |
| 15 | Cefotaxime | Antibiotic | |
| 16 | 3-Nitropropionic acid | Mycotoxin | |
| 17 | Furosemide | Asthma (48) | Diuretic |
| 18 | Boldine | Alkaloid | |
| 19 | Fulvestrant | Chemotherapy | |
| 20 | Levothyroxine sodium | Asthma* (9) | Synthetic thyroxine |
| 21 | Homatropine | Anticholinergic | |
| 22 | Sulfaquinoxaline | Antiprotazoal | |
| 23 | Terguride | Serotonin antagonist and dopamine agonist | |
| 24 | Naftifine | Antifungal | |
| 25 | Raubasine | Antihypertensive |
Rank is order of correlation. CMAP, connectivity map; HSP, heat shock protein.
*
Adverse effect.