Table 4.
CMAP Compounds that reversed signature 1
| Rank | Drug | Condition (Reference) | Classification/Use |
|---|---|---|---|
| 6076 | Etofylline | Asthma (94) | Bronchodilator |
| 6077 | (−)-Atenolol | Beta adrenergic receptor antagonist | |
| 6078 | Mevalolactone | Chemical compound | |
| 6079 | Ornidazole | Antiprotozoal | |
| 6080 | Solasodine | Alkaloid | |
| 6081 | Flunisolide | Asthma* (20) | Glucocorticoid |
| 6082 | Etacrynic acid | Bronchoconstriction (63) | Diuretic |
| 6083 | Tanespimycin | HSP90 inhibitor | |
| 6084 | Etamivan | Asthma (83) | Respiratory stimulant |
| 6085 | Solanine | Alkaloid | |
| 6086 | Procaine | Asthma (80) | Local anesthetic |
| 6087 | Ciprofloxacin | Antibiotic | |
| 6088 | Valproic acid | Hyperresponsiveness (68) | Anticonvulsant |
| 6089 | Alvespimycin | HSP90 inhibitor | |
| 6090 | Isoetarine | Asthma* (45) | Bronchodilator |
| 6091 | Valproic acid | Hyperresponsiveness (68) | Anticonvulsant |
| 6092 | Wortmannin | Hyperresponsiveness (26) | Phosphatidylinositol 3-kinase inhibitor |
| 6093 | Furaltadone | Antibiotic | |
| 6094 | Sirolimus | Asthma (54) | Immunosuppressant |
| 6095 | Oxymetazoline | Asthma (35) | Decongestant |
| 6096 | Homatropine | Anticholinergic | |
| 6097 | Urapidil | Bronchospasm (53) | Antihypertensive |
| 6098 | Minocycline | Asthma (19) | Antibiotic |
| 6099 | Estriol | Estradiol metabolite | |
| 6100 | Spironolactone | Diuretic |
Rank is order of correlation. CMAP, connectivity map; HSP, heat shock protein.
*
Approved for clinical treatment of asthma.