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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: NanoImpact. 2018 Feb 21;11:82–91. doi: 10.1016/j.impact.2018.02.007

Figure 4.

Figure 4

Exposure to TiO2, SiO2 and PS NPs disrupted endothelial barrier function in HUVEC. HUVEC were exposed to TiO2, SiO2 and PS NPs at the concentrations that three types of NPs have the same total surface area (8.76 μg/mL or 2.65 μg/cm2 for TiO2 NPs, 5.48 μg/mL or 1.66 μg/cm2 for SiO2 NPs, 2.18 μg/mL or 0.66 μg/cm2 for PS NPs). Control was treated with fresh EGM-2. FITC-dextran fluorescence in the bottom chamber was measured after 2 hours of exposure to all three types of NPs. Mean ± standard deviation (SD) of the sample. Data were analyzed by one way ANOVA, * represents significant difference compared with untreated HUVEC, # denotes significant difference between different NPs, n = 3, p < 0.05.