Table 1.
Four retrospective case series looking at conversion surgery after chemotherapy for advanced/metastatic gastric cancer
First author | Time of accrual | Eligibility | Chemotherapeutic regimen | Indication for surgery | No. of patients who received chemotherapy | No. of patients who received gastrectomy | % treated by gastrectomy | No. of patients who received R0 resection | Rate of R0 resection among all surgeries | MST of patients who received surgery | MST of the R0 resected patients |
---|---|---|---|---|---|---|---|---|---|---|---|
Yamaguchi16 | 2001‐2013 | cStage IV | Various doublets/triplets | R0 resection possible | 259 | 84 | 32.4 | 43 | 51.2 | 30.5 | 41.3 |
Fukuchi17 | 2003‐2013 | Any one of the following: cT4b, P1, H1, CY1, M1 | S‐1/CDDP or S‐1/paclitaxel | R0 resection possible | 151 | 40 | 26 | 32 | 80 | 53 | 62 |
Sato18 | 2002‐2014 | cStage IV | S‐1/CDDP/docetaxel | R0 resection possible | 100 | 33 | 33 | 28 | 85 | 47.8 | 47.9 |
Ishigami19 | 2005‐2011 | P1 or CY1 | S‐1/paclitaxel IV/paclitaxel IP | CY0, disappearance of shrinkage of peritoneal mets | 100 | 64 | 64 | 44 | 68.8 | 30.5 | NA |
The fourth series was restricted to patients who underwent intraperitoneal chemotherapy for peritoneal metastases.
IP, intraperitoneal chemotherapy; mets, metastases; MST, median survival time (months); NA, not available.