Table 4.

Summary of Treatment Trials with Endovascular Therapy

Name of trial	No. Of pts.	Mode of Intervention	Time Window (Hour)	Primary endpoint	Imaging selection
MR CLEAN	500	Endovascular treatment (stent retrievers 81.5%) plus usual care (87.1% IVT)	0–6	mRS at 90 days (mRS 0–2)	CT, CTA
ESCAPE	316	Endovascular treatment (stent retrievers 86.1%) plus standard care (72.7% IVT)	0–12	mRS at 90 days (OR for 1 point improvement in mRS)	CT, CTA (good/moderate collaterals), CTA Alberta Stroke Program Early CT score (ASPECTS).
EXTEND-IA	70	Endovascular thrombectomy (Solitaire FR stent retriever) plus IVT < 4.5 h	0–6	Reperfusion 24 h Early neurological improvement	CT, CTA, CT perfusion Core/mismatch-RAPID
SWIFT PRIME	196	Endovascular thrombectomy (Solitaire stent retriever) plus IVT <4.5 h	0–6	mRS shift at 90 days	CT, CTA, CT/MR perfusion, core/mismatch and ASPECTS.
REVASCAT	206	Endovascular thrombectomy (Solitaire stent retriever) plus usual care (77% IVT)	0–8	mRS shift at 90 days	CT, CTA, ASPECTS.

^*IVT=intravenous thrombolysis; mRs=Modified Ranklin scale; FR=Flow restoration