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. 2018 Sep 17;16:151. doi: 10.1186/s12916-018-1142-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Cohort construction using CPRD participating practice registered children born between January 2000 and March 2013. Children leave the cohort at the end of the study period (31/12/2013). Consequently, children leave the cohort at varying ages, for example, those born in 2013 will only be represented in the cohort’s < 1 year age group. Children may also leave the cohort before the end of the study period if the last practice data collection date was prior to the end of the study period, if they reach their 10th birthday or if they leave their registered practice