Table 1.
Materials that affect BPIFA1 expression.
| Effector of BPIFA1 expression | Study design materials | Correlated diseases | Disease findings | Mechanism/pathway | Biofilm correlation /pathogen |
|---|---|---|---|---|---|
| IL-13 | Human nasal lavage fluid | Allergic rhinitis | Lower in allergy | ERK | Not mentioned /not mentioned |
| Tissue specimens by sinus surgery | LPS treated RPMI-2650 |
Lower in polyps tissue | JNK, AP1 | Not mentioned/LPS toxin | |
|
| |||||
| Lactoferrin | RPMI-2650 cells | LPS treated RPMI-2650 |
Recovery of BPIFA1 | Inhibition of MEK/ERK pathway | Not mentioned /LPS toxin |
|
| |||||
| Intranasal steroid | RPMI-2650 cells | LPS treated RPMI-2650 |
Recovery of BPIFA1 | Reactivation of AP-1 | Not mentioned /LPS toxin |
|
| |||||
| MMP9 (matrix metallo-proteinase 9) | Targets cells/macrophages/oral epithelia/airway epithelia | PLUNCS inhibited by MMP9 | PLUNCS inhibited | PLUNC protein proteolytically cleaved by MMP9 | Not mentioned /microorganism colonization |