Table 6.

QUADAS-2 Evaluation.

Study	Risk of Bias				Applicability concerns
	Patient selection	Index test	Reference standard	Flow and timing	Patient selection	Index test	Reference standard
Bisenius et al., 2017	Low	Low	Low	Low	Low	Low	Low
Bron et al., 2017	Low	Low	Low	Low	Low	Low	Low
Canu et al., 2017	High	Low	Low	Low	Low	Low	Low
Chow et al., 2008	Low	High	Low	Low	Low	Low	Low
Davatzikos et al., 2008	Low	Unclear	Low	Low	Low	Low	Low
Du et al., 2007	Low	Low	Low	Low	Low	Low	Low
Dukart et al., 2011	High	Low	Low	Low	Low	Low	Low
Frings et al., 2014	Low	High	Low	Low	Low	Low	Low
Klöppel et al., 2008a, Klöppel et al., 2008b	Low	Low	Low	Low	Low	Low	Low
Klöppel et al., 2015	Low	Low	Low	Low	Low	Low	Low
Koikkalainen et al., 2016	Low	Low	Low	Low	Low	Low	Low
Kuceyeski et al., 2012	Low	Low	Low	Low	Low	Low	Low
Lehmann et al., 2010	Low	Low	Low	Low	Low	Low	Low
Mahoney et al., 2014	Low	High	Low	Low	Low	Low	Low
McMillan et al., 2012	Low	High	Low	Low	Low	Low	Low
McMillan et al., 2014	Low	Low	Low	Low	Low	Low	Low
Meyer et al., 2017	Low	Low	Low	Low	Low	Low	Low
Möller et al., 2015	High	High	Low	Low	Low	Low	Low
Möller et al., 2016	Low	Low	Low	Low	Low	Low	Low
Muñoz-Ruiz et al., 2012	High	Unclear	Low	Low	Low	Low	Low
Raamana et al., 2014	Low	Low	Low	Low	Low	Low	Low
Tahmasian et al., 2016	High	Low	Low	Low	Low	Low	Low
Tong et al., 2017	Low	Low	Low	Low	Low	High	Low
Vemuri et al., 2011	Low	High	Low	Low	Low	Low	Low
Wang et al., 2016	Low	Low	Low	Low	Low	Low	Low
Whitwell et al., 2011	Low	High	Low	Low	Low	Low	Low
Wilson et al., 2009	Low	Low	Low	Low	Low	Low	Low
Zhang et al., 2013	High	High	Low	Low	Low	Low	Low