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. Author manuscript; available in PMC: 2019 Aug 16.
Published in final edited form as: Mol Cell. 2018 Aug 2;71(4):554–566.e7. doi: 10.1016/j.molcel.2018.06.040

Figure 1.

Figure 1.

SILAC mass spectromety for ERG-interacting proteins reveals subunits of BAF complexes.

(A) Schematic of TMPRSS2-ERG gene fusion that results in aberrant ERG expression levels.

(B) Schematic of SILAC mass spectrometry experiment in TMPRSS2-ERG-containing VCaP prostate cancer cells.

(C) SILAC mass-spectrometry screen for ERG interactors reveals significant enrichment of BAF complex subunits. Anti-ERG SILAC hits are plotted as log2-fold change for each experimental replicate. Highlighted are ERG (green) and BAF complex subunit components (red).

(D) Table of mammalian SWI/SNF protein subunits identified in proteomic mass-spectrometry, indicating number of unique peptides, sequence coverage (%), associated p-values, and rank among the full set of enriched proteins.