Fig. 13.

The sustained release of drugs. a) SEM images of chitosan microspheres with three different structures and their in vitro BSA release profiles.¹⁴³ Reprinted with permission from ref. 143. Copyright 2012, John Wiley & Sons, Inc. b) Optical images of the eccentric and core-centered internal structures, and release profiles of rhodamine 6G from the four types of microcapsules with and without ultrasound.¹⁶⁸ Reprinted with permission from ref. 168. Copyright 2014, The Royal Society of Chemistry. c) The fabrication of multi-drugs loaded polymer/porous silicon (PSi) composite microparticles for multi-stage release of AVA drugs in different pH conditions.¹⁶⁹ Reprinted with permission from ref. 169. Copyright 2014, John Wiley & Sons, Inc. d) Schematic illustration of the multi-stimuli-responsive microcapsules with adjustable controlled-release.¹⁷³ Reprinted with permission from ref. 173. Copyright 2014, John Wiley & Sons, Inc. e) Schematic illustration of a triple polymersome showing bilayers with no internal homopolymer on the top right and two of the bilayers containing homopolymer on the bottom right. Series of confocal images showing the sequential dissociation of these two kinds of membranes in the mixture of water and ethanol.¹⁰² Reprinted with permission from ref. 102. Copyright 2011, American Chemical Society.