Microparticle-based biosensors. a) PEG-based microparticles produced in PDMS device for measuring the concentration of glucose in vitro.248 Reprinted with permission from ref. 248. Copyright 2012, AIP Publishing. b) Microcapsule-based biosensor encapsulating quantum dots or gold nanorods for the detection of glucose and heparin.249 Reprinted with permission from ref. 249. Copyright 2018, The Royal Society of Chemistry. c) Hydrogel microspheres with tunable chemical functionalities for biomolecular conjugation reactions.250 Reprinted with permission from ref. 250. Copyright 2017, American Chemical Society. d) Microparticles encoded with colored core droplets and functionalized silica nanoparticles for multiplex immunoassay.115 Reprinted with permission from ref. 115. Copyright 2011, John Wiley & Sons, Inc. (e) Microparticle biosensors for monitoring the glucose concentration in vivo.253 Reprinted with permission from ref. 253. Copyright 2010, National Academy of Sciences.