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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Placenta. 2018 Jul 10;69:32–39. doi: 10.1016/j.placenta.2018.07.005

Figure 2:

Figure 2:

Stimulation of human P-gp and human BCRP ATPase activity by direct-acting antiviral drugs. Stimulation of ATPase activity was estimated by measuring inorganic phosphate released from ATP in the presence or absence of their respective controls for sofosbuvir, entecavir, and tenofovir (20 and 100 μM). The drug-stimulated ATPase activity was reported as fold-stimulation relative to the basal ATPase activity in the absence of drug (DMSO control). Data are represented as mean fold stimulation of the average control from triplicate reactions. *P ⩽ 0.05.