Figure 3:

Transport of direct acting antiviral drugs by ABC and SLC transporters in placental cells. The cellular accumulation of radiolabeled sofosbuvir, entecavir, and tenofovir was evaluated in [A] BeWo b30 cells (n=3) and [B] PHT (n=4–5) in the presence of chemical inhibitors of P-gp, BCRP, and ENT1/2. Samples were run in triplicate and data represented as mean ± S.E.M. Statistical differences were determine by either unpaired or paired t-test, *P ⩽ 0.05.