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Multiple immune checkpoint and ligand-receptor interactions between T cell and APC or DLBCL malignant cells regulate T cell activation and anti-tumor activity. APC, antigen presenting cell; DLBCL, diffuse large B cell lymphoma; PD1, programmed cell death protein 1; PD-L, programmed cell death ligand; GAL9, galectin 9; TIM3, T cell membrane protein 3; B7RP1, B7-related protein 1; ICOS, inducible T cell co-stimulator; MHC, major histocompatibility complex; TCR, T cell receptor.
