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. 2018 Oct;24(10):1277–1284. doi: 10.1261/rna.067736.118

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© 2018 Han and Phizicky; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 4. — Three possible mechanisms to explain the ordered modification circuits in the ACL region, using the i⁶A₃₇/t⁶A₃₇-m³C₃₂ circuit as an example. (A) The initial modification (i⁶A₃₇ or t⁶A₃₇) directly acts as a recognition element for the subsequent modification enzyme (Trm140 for m³C₃₂ modification). (B) The initial modification (i⁶A₃₇ or t⁶A₃₇) alters the structure of the ACL to present a structure that is itself recognized or properly exposes the target residue (C₃₂) for the subsequent modification enzyme (Trm140). (C) The initial modification (i⁶A₃₇ or t⁶A₃₇) prevents a subsequent modification from occurring (Cm₃₂ by Trm7/732), allowing a different modification enzyme (Trm140) to act instead.