Fig. 3.

Alignment of representative ArrA and ArxA sequences highlighting the active-site residues. A more complete comparison that includes accession numbers is provided in SI Appendix, Fig. S6. Annotated ArrA enzymes contain a (R/K)GRY motif (blue), while annotated ArxA sequences contain a XGRGWG motif (green). Other active-site residues are generally conserved between ArrA and ArxA (pink), including the Mo-coordinating Cys residue (yellow). Sequence numbers are relative to the ArrA from Shewanella sp. ANA-3.