Table 1.
cell numbers and expression of MHCII by monocyte cells; as well as levels of IL-6, TNFα and CRP in plasma samples of patients. N.D.: not determined. Two tailed Wilcoxon signed-rank tests were used to test the differences in patients’ blood or plasma samples. P values <0.05 (indicated in bold) were considered significantly different.
| Pt 1 | Pt 2 | Pt 3 | Pt 4 | Pt 5 | Pt 6 | Pt 7 | Pt 8 | Pt 9 | pre-per | pre-post | per-post | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WBC (x106 cell/ml) | ||||||||||||
| pre- | 7 | 5.2 | 6.6 | 5.4 | 3.6 | 5.7 | 7.2 | 6.5 | 3.2 | p = 0.025 | p = 0.033 | p = 0.67 |
| per- | 19.3 | 8.3 | ND | 4.9 | 10.4 | 9.9 | 8.8 | 6.7 | 5.2 | |||
| post- | 23.7 | 60 | 12.8 | 21.6 | 6.5 | 9.6 | 7.3 | 6.4 | 2.3 | |||
| Lymphocytes (x106 cell/ml) (%) | ||||||||||||
| pre- | ND | ND | 1.78 (27) | 1.62 (30) | 0.72 (20) | 0.63 (11) | 0.29 (4) | 1.37 (21) | 0.22 (7) | p = 0.25 | p = 0.18 | p = 0.46 |
| per- | ND | ND | ND | 1.03 (21) | 0.73 (7) | 0.60 (6) | 0.26 (3) | 0.94 (14) | 0.57 (11) | |||
| post- | ND | ND | 1.79 (14) | 1.94 (9) | 0.52 (8) | 0.10 (1) | 0.22 (3) | 0.96 (15) | 0.21 (9) | |||
| Monocytes (x106 cell/ml) (%) | ||||||||||||
| pre- | ND | ND | 0.66 (10) | 0.65 (12) | 0.29 (8) | 0.74 (13) | 1.01 (14) | 1.76 (27) | 0.67 (21) | p = 0.75 | p = 1.00 | p = 0.46 |
| per- | ND | ND | ND | 0.64 (13) | 0.94 (9) | 0.50 (5) | 1.06 (12) | 1.47 (22) | 0.94 (18) | |||
| post- | ND | ND | 0.90 (7) | 1.94 (9) | 0.65 (10) | 0.58 (6) | 0.73 (10) | 1.34 (21) | 0.37 (16) | |||
| Granulocytes (x106 cell/ml) (%) | ||||||||||||
| pre- | ND | ND | 4.16 (63) | 3.13 (58) | 2.60 (72) | 4.33 (76) | 5.90 (82) | 3.45 (53) | 2.30 (72) | p = 0.028 | p = 0.043 | p = 0.46 |
| per- | ND | ND | ND | 3.19 (65) | 8.74 (84) | 8.81 (89) | 7.66 (87) | 4.29 (64) | 3.69 (71) | |||
| post- | ND | ND | 10.11 (79) | 17.7 (82) | 5.33 (82) | 8.93 (93) | 6.35 (87) | 4.10 (64) | 0.37 (75) | |||
| MHCII (geomean) | ||||||||||||
| pre- | 222 | 1010 | 837 | 7 | 444 | 21 | 179 | 357 | 278 | p = 0.092 | p = 0.066 | p = 0.25 |
| per- | 139 | 845 | ND | 9 | 219 | 7 | 165 | 420 | 232 | |||
| post- | 153 | 537 | 612 | 9 | 211 | 7 | 181 | 390 | 201 | |||
| IL-6 (pg/ml) | ||||||||||||
| pre- | 0 | 0 | 0 | 0 | 5.9 | 9.2 | 0 | 0 | 0 | p = 0.11 | p = 0.012 | p = 0.018 |
| per- | 0 | 14.4 | ND | 0 | 116.8 | 13.9 | 0 | 0 | 0 | |||
| post- | 40.8 | 187.2 | 22.6 | 57.9 | 351.4 | 105.8 | 4.6 | 0 | 4.6 | |||
| TNFα (pg/ml) | ||||||||||||
| pre- | 0 | 3.91 | 38.79 | 0.93 | 4.9 | 23.23 | 3.66 | 4.4 | 12.98 | p = 0.61 | p = 0.050 | p = 0.091 |
| per- | 0 | 7.49 | ND | 0.53 | 7.49 | 16.7 | 5.15 | 2.71 | 7.75 | |||
| post- | 0 | 3.66 | 32.47 | 0.02 | 4.15 | 17.87 | 4.65 | 2.02 | 6.44 | |||
| CRP (μg/ml) | ||||||||||||
| pre- | >5.50 | 0.28 | >5.50 | 0.23 | 0.61 | 4.00 | 1.56 | 0.29 | 0.21 | p = 1.00 | p = 0.89 | p = 0.89 |
| per- | 2.36 | 0.22 | ND | 0.32 | 0.73 | 2.27 | 1.78 | 0.27 | 0.45 | |||
| post- | 2.32 | 0.39 | >5.50 | 0.20 | 0.124 | 4.23 | 1.59 | 0.74 | 0.24 |