Table 3.
ID | Cellular Subset | Antigen Density (# molecules/cell) |
EC50 (pM) | ||
---|---|---|---|---|---|
CD33 | CD123 | CD33 + CD123 | |||
P9 (AML-M2) | Bulk (CD45dim SSClow) | 5,500 | 2,500 | 8,500 | 166 |
CD34-enriched MNCs | 13,000 | 9,100 | 22,100 | 43 | |
P11 (AML-M4) | Bulk (CD45dim SSClow) | 1,200 | 2,400 | 3,600 | 1,078 |
CD34-enriched MNCs | 500 | 14,500 | 15,000 | 681 | |
LSC-enriched fraction (CD34+ CD38− CD123+) |
300 | 18,000 | 18,300 | ND |
ND: not determined