Table 2.
Effects of increasing dialysate magnesium on T50 and related biomarkers
| Variable | Baseline | Follow-Up | Change from Baseline to Follow-Up (95% CI) | Between-Group Difference at Follow-Up (95% CI) | P Value for Difference at Follow-Up |
|---|---|---|---|---|---|
| T50, min | 73 (30 to 116) | 0.001 | |||
| Standard dialysate Mg | 233±81 | 229±93 | −4 (−26 to 17) | ||
| High dialysate Mg | 247±69 | 302±66 | 54 (31 to 78)a | ||
| Mg, mg/dl | 0.9 (0.7 to 1.1) | 0.001 | |||
| Standard dialysate Mg | 2.4±0.3 | 2.5±0.3 | 0.1 (−0.0 to 0.2) | ||
| High dialysate Mg | 2.4±0.4 | 3.4±0.5 | 0.9 (0.8 to 1.1)a | ||
| PO4, mg/dl | −0.4 (−1.0 to 0.3) | 0.24 | |||
| Standard dialysate Mg | 5.0±1.3 | 4.9±1.3 | −0.1 (−0.5 to 0.3) | ||
| High dialysate Mg | 4.7±0.9 | 4.5±1.0 | −0.2 (−0.6 to 0.1)b | ||
| Ionized Ca, mg/dl | −0.0 (−0.2 to 0.1) | 0.53 | |||
| Standard dialysate Mg | 4.6±0.2 | 4.6±0.3 | −0.1 (−0.1 to 0.0) | ||
| High dialysate Mg | 4.6±0.4 | 4.5±0.3 | −0.0 (−0.1 to 0.0) | ||
| Fetuin-A, g/L | 0.01 (−0.03 to 0.05) | 0.55 | |||
| Standard dialysate Mg | 0.31±0.07 | 0.31±0.07 | 0.00 (−0.01 to 0.02) | ||
| High dialysate Mg | 0.32±0.06 | 0.32±0.07 | 0.00 (−0.01 to 0.01) | ||
| HCO3, mEq/L | −0 (−1 to 1) | 0.79 | |||
| Standard dialysate Mg | 25±2 | 25±2 | 0 (−0 to 1) | ||
| High dialysate Mg | 24±3 | 25±2 | 1 (0 to 1)c | ||
| Albumin, g/dl | 0.0 (−0.2 to 0.2) | 0.87 | |||
| Standard dialysate Mg | 3.2±0.4 | 3.3±0.4 | 0.1 (−0.0 to 0.1)c | ||
| High dialysate Mg | 3.3±0.3 | 3.3±0.4 | 0.0 (−0.1 to 0.1) | ||
| PTH, pg/ml | −21% (−41% to 6%) | 0.12 | |||
| Standard dialysate Mg | 278 (199–359) | 311 (207–347) | 14% (1% to 28%) | ||
| High dialysate Mg | 328 (206–387) | 238 (165–366) | −21% (−28% to −13%)b |
Baseline and follow-up values are described as mean±SD or median and interquartile range. Changes from baseline to follow-up are described as mean change with 95% CI. Change over time was analyzed using linear mixed models. Baseline was defined as the mean of measurements on days −7 and 0, and follow-up was defined as the mean of measurements on days 21 and 28. 95% CI, 95% confidence interval; T50, serum calcification propensity; Mg, magnesium; PO4, phosphate; Ca, calcium; HCO3, bicarbonate; PTH, intact parathyroid hormone.
Change from baseline to end of follow-up is significant at P<0.001.
Change from baseline to end of follow-up is significant at P<0.01.
Change from baseline to end of follow-up is significant at P<0.05.