Table 2.
Association between incident atrial fibrillation and subsequent risk of death and stroke among adults with nondialysis-dependent CKD
Total No. of Events | Nonatrial Fibrillation N Event (IR per 1000 person-yr)a | Incident Atrial Fibrillation N Event (IR per 1000 person-yr)a | Adjusted Hazard Ratio (95% CI)b | P Value | |
---|---|---|---|---|---|
All-cause death | 34,205 | 28,613 (67.5) | 5592 (205.1) | 1.76 (1.71 to 1.82) | <0.001 |
All-cause stroke | 8238 | 6850 (16.6) | 1388 (53.8) | 2.00 (1.88 to 2.14) | <0.001 |
Ischemic stroke | 6355 | 5251 (12.6) | 1104 (42.5) | 2.11 (1.96 to 2.28) | <0.001 |
Intracranial bleed | 2054 | 1762 (4.2) | 292 (10.8) | 1.64 (1.42 to 1.91) | <0.001 |
IR, incidence rate; 95% CI, 95% confidence interval.
IRs per person-years for study outcomes after incident atrial fibrillation and during nonatrial fibrillation periods.
Adjusted hazard ratios for study outcomes associated with the development of incident atrial fibrillation. Multivariable adjustment included age, sex, eGFR, history of intracranial bleeding, history of heart failure, anemia, hypertension, diabetes, vascular disease, prior stroke, transient ischemic attack, percutaneous coronary intervention, coronary artery bypass grafting, peripheral arterial disease, pulmonary embolism, deep venous thrombosis, valvular disease, liver disease, thyroid disease, chronic obstructive pulmonary disease, cancer, alcohol abuse, and dementia as well as use of warfarin, aspirin, clopidogrel, selective serotonin reuptake inhibitors, and proton pump inhibitors.