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. 2018 Jul 20;13(9):1314–1320. doi: 10.2215/CJN.04060318

Table 2.

Association between incident atrial fibrillation and subsequent risk of death and stroke among adults with nondialysis-dependent CKD

Total No. of Events Nonatrial Fibrillation N Event (IR per 1000 person-yr)a Incident Atrial Fibrillation N Event (IR per 1000 person-yr)a Adjusted Hazard Ratio (95% CI)b P Value
All-cause death 34,205 28,613 (67.5) 5592 (205.1) 1.76 (1.71 to 1.82) <0.001
All-cause stroke 8238 6850 (16.6) 1388 (53.8) 2.00 (1.88 to 2.14) <0.001
Ischemic stroke 6355 5251 (12.6) 1104 (42.5) 2.11 (1.96 to 2.28) <0.001
Intracranial bleed 2054 1762 (4.2) 292 (10.8) 1.64 (1.42 to 1.91) <0.001

IR, incidence rate; 95% CI, 95% confidence interval.

a

IRs per person-years for study outcomes after incident atrial fibrillation and during nonatrial fibrillation periods.

b

Adjusted hazard ratios for study outcomes associated with the development of incident atrial fibrillation. Multivariable adjustment included age, sex, eGFR, history of intracranial bleeding, history of heart failure, anemia, hypertension, diabetes, vascular disease, prior stroke, transient ischemic attack, percutaneous coronary intervention, coronary artery bypass grafting, peripheral arterial disease, pulmonary embolism, deep venous thrombosis, valvular disease, liver disease, thyroid disease, chronic obstructive pulmonary disease, cancer, alcohol abuse, and dementia as well as use of warfarin, aspirin, clopidogrel, selective serotonin reuptake inhibitors, and proton pump inhibitors.