Table 1.
Summary of the treatment prescription for hemodiafiltration
| Parameter | Target Range |
|---|---|
| Hemodialyzer | |
| Membrane | High flux, 1.6–2.2 m2 |
| Fiber internal diameter | ≥200 μm |
| Ultrafiltration coefficient | >20 ml/h per 1 mm Hg per 1 m2 |
| Sieving coefficient | >0.6 for β2-Microglobulin; <0.001 for albumin |
| Vascular access | |
| AVF or AVG; tunneled central venous catheter | Needles, 14–15 g |
| Blood flow rate | 350–450 ml/min |
| Dialysate flow rate | |
| Total (including substitution solution) | 600–1000 ml/min |
| Dialyzer | 500–600 ml/min |
| Convection volume | |
| Postdilution | 23 L per treatment or 26 L/1.73 m2 |
| Predilution | 46 L per treatment or 52 L/1.73 m2 |
| Mid-dilution or mixed dilution | 35 L per treatment or 40 L/1.73 m2 |
| Ultrafiltration control | |
| Manual | TMP<400 mm Hg, filtration fraction <0.25 |
| Automated | TMP=105–300 mm Hg |
| Anticoagulation | |
| Unfractionated heparin | No dose adjustment |
| Low molecular weight heparin | Dose and injection site adjustment |
| Dialysate composition | Adjusted according to patient need and convection volume |
AVF, arteriovenous fistula; AVG, arteriovenous graft; TMP, transmembrane pressure.