Figure 2.

Correlation of 25-OH vitamin D serum level and HPV status in HNSCC patients with overall survival. A Kaplan-Meier analysis is shown in (A) for a vitamin D high group (black line; 25-OH vitamin D ≥ 15 ng/ml; n = 76) and a vitamin D low group (grey line; 25-OH vitamin D < 15 ng/ml; n = 155). It revealed a significantly worse prognosis for vitamin D deficient patients (p = 0,0085; log-rank test). HPV positive tumor status (n = 35) correlated with improved overall survival in the analyzed HNSCC patients (B). Low vitamin D serum levels were a predictor of poor overall survival (OS) in HPV negative patients (C), while vitamin D supply had no influence on the OS in HPV positive HNSCC patients (D). Black or grey dots represent censored data.

HPV+: positive HPV status; HPV-: negative HPV status